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Mental health

Antidepressants in general

Any antidepressant
Other names: antidepressant, SSRI, SNRI

FAA guidance

Special issuance required.

Source: FAA, Antidepressants. FAA date 24 April 2024. Checked by Crosscheck 14 October 2026

The Guide's Antidepressants page says individuals can be considered for first-, second- or third-class certificates while being treated with one of several specific antidepressants.

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Compare FAA documents: Antidepressants in generalWhat each of the two FAA documents says, in plain wordsOpen

The Authorization decision is made case by case, and the examiner may not issue. It says mental health medications generally have central nervous system effects and take some time to become effective, and so have long initial observation time considerations.

The FAA's antidepressant table lists which antidepressants are conditionally acceptable and which are unacceptable; each has its own entry here.

Show the FAA's words: Antidepressants in generalThe official FAA wording: two passages, each with its document and dateOpen
FAA, Antidepressants · FAA date 24 April 2024
Individuals can be considered for first, second, or third-class medical certificates while being treated with one of several specific antidepressants. The Authorization decision is made on a case-by-case basis. The AME may not issue. Medications used in mental health generally have central nervous system effects and take some time to become effective, and therefore have long initial observation time considerations.
FAA, Antidepressant Medications (table) · FAA date 27 August 2025
UNACCEPTABLE Antidepressant Medications (Used as a single agent or in any combination product.)
Sources and dates: Antidepressants in generalTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.