Crosscheck

Your medical. Crosschecked.

Bones

Denosumab

RANK ligand inhibitor
Other names: Prolia

FAA guidance

Acceptable with conditions.

Wait

48 hours

initial observation

Different waits apply in other cases.

Examiner

The examiner can issue when the document's criteria are met

FAA label

ACCEPTABLE

Source: FAA, Osteoporosis Medications. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists denosumab as acceptable osteoporosis medication when the certification criteria are met, with a 48-hour initial observation and four hours after each dose; cancer-related use may carry extra requirements.

Track your medications
More detail: denosumabThe rest of the wait, and the FAA rules behind this answerOpen

Wait

  • 4 hours after each dose
  • 48 hours after starting: ground observation
  • 4 hours after each dose: ground observation
Show the FAA's words: denosumabThe official FAA wording: one passage, each with its document and dateOpen
FAA, Osteoporosis Medications · FAA date 26 August 2026
ACCEPTABLE Osteoporosis Medications (when certification criteria are met). RANK ligand inhibitors: denosumab (Prolia), 48 hours, 4 hours. Above guidance is for osteoporosis treatment ONLY. If used for cancer-related conditions, additional observation periods and/or requirements may apply.
Sources and dates: denosumabOne FAA document, with the FAA's date and when Crosscheck checked itOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.