Crosscheck

Your medical. Crosschecked.

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Mental health

Esketamine

Antidepressant nasal spray
Other names: Spravato

FAA guidance

Do not issue.

Examiner

Do not issue: the examiner cannot issue a certificate

FAA label

UNACCEPTABLE

Source: FAA, Antidepressant Medications (table). FAA date 27 August 2025. Checked by Crosscheck 14 October 2026

The FAA lists esketamine as an unacceptable antidepressant.

Track your medications
Show the FAA's words: esketamineThe official FAA wording: one passage, each with its document and dateOpen
FAA, Antidepressant Medications (table) · FAA date 27 August 2025
UNACCEPTABLE Antidepressant Medications (Used as a single agent or in any combination product.) — esketamine (Spravato) All tricyclic antidepressants (TCAs) All monoamine oxidase inhibitors (MAO-I)
Sources and dates: esketamineOne FAA document, with the FAA's date and when Crosscheck checked itOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.