Crosscheck

Your medical. Crosschecked.

Blood pressure

Guanabenz

Centrally acting antihypertensive
Other names: Wytensin

FAA guidance

Do not issue.

Examiner

Do not issue: the examiner cannot issue a certificate

FAA label

DO NOT ISSUE

Source: FAA, Antihypertensive (HTN, blood pressure medication). FAA date 30 September 2026. Checked by Crosscheck 14 October 2026

The FAA's antihypertensive sheet lists guanabenz as unacceptable blood pressure medication, as a single agent or in any combination product, under Do Not Issue.

Track your medications
Compare FAA documents: guanabenzWhat each of the two FAA documents says, in plain wordsOpen

The FAA's Do Not Issue table also names guanabenz, under centrally acting hypertensives, and the FAA's table says the examiner should defer the exam; it also says do not issue a medical certificate.

FAA rule for blood pressure medication: The FAA's hypertension worksheet (CACI) refers to the antihypertensive sheet for acceptable medications, and allows combinations of up to 3 of the classes it lists -- alpha blockers, beta-blockers, calcium channel blockers, diuretics, ACE inhibitors, ARBs, direct renin inhibitors and direct vasodilators -- and lists centrally acting antihypertensives, such as clonidine, as not acceptable. The Guide's hypertension table says the number of medications counts each component (for example, lisinopril/HCTZ is 2 medications), and that with 4 or more acceptable medications the examiner should defer. FAA, CACI – Hypertension Worksheet

Show the FAA's words: guanabenzThe official FAA wording: two passages, each with its document and dateOpen
FAA, Antihypertensive (HTN, blood pressure medication) · FAA date 30 September 2026
UNACCEPTABLE HTN Medications (as a single agent or in any combination product)
DO NOT ISSUE
Clonidine (ex. Catapres/Clorpres)
guanabenz
guanfacine/Tenex
methyldopa
FAA, DO NOT ISSUE – DO NOT FLY Medications and general No Fly wait times · FAA date 30 September 2026
DO NOT ISSUE (DNI) MEDICATIONS
If the applicant is taking any of the following medications, AMEs should DEFER the exam. DO NOT issue a medical certificate to applicants who are using any of the following drug classes or medications for any condition:
HYPERTENSIVE (CENTRALLY ACTING)
Including but not limited to:
clonidine
guanabenz, methyldopa
Sources and dates: guanabenzTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.