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Stomach

H2 blockers

H-2 blocker
Other names: famotidine, Pepcid, cimetidine, Tagamet, nizatidine, Axid

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

Examiner

The examiner can issue when the document's criteria are met

Source: FAA, Antacids. FAA date 27 December 2016. Checked by Crosscheck 14 October 2026

The FAA says H-2 blockers taken to prevent symptoms may not be disqualifying if free from side effects, and its over-the-counter guide lists cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac) for indigestion.

Track your medications
Compare FAA documents: H2 blockersWhat each of the three FAA documents says, in plain wordsOpen

The FAA's MedGuide names cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid) and ranitidine (Zantac) as allowed, for stomach ulcers, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: H2 blockersThe official FAA wording: three passages, each with its document and dateOpen
FAA, Antacids · FAA date 27 December 2016
The prophylactic use of medications including simple antacids, H-2 inhibitors or blockers, proton pump inhibitors, and/or sucralfates may not be disqualifying, if free from side effects.
Generic: cimetidine
Brand Name: Tagamet
Drug Class: H2 Blocker (Histamine H2 Antagonist)
Underlying Condition: Stomach ulcers
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
Generic: famotidine
Brand Name: Pepcid
Drug Class: H2 Blocker (Histamine H2 Antagonist)
Underlying Condition: Stomach ulcers
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
Generic: nizatidine
Brand Name: Axid
Drug Class: H2 Blocker (Histamine H2 Antagonist)
Underlying Condition: Stomach Ulcers
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
Generic: raNITIdine
Brand Name: Zantac
Drug Class: H2 Blocker (Histamine H2 Antagonist)
Underlying Condition: Stomach ulcers
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
cimetidine (Tagamet)
famotidine (Pepcid)
nizatidine (Axid)
rantidine (Zantac)
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: H2 blockersThree FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.