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JAK inhibitors

Janus associated kinase (JAK) inhibitor (non-biologic)
Other names: tofacitinib, Xeljanz, upadacitinib, Rinvoq, baricitinib, Olumiant

FAA guidance

Acceptable with conditions.

Wait

2 weeks

ground trial when starting

Other FAA documents add more.

Examiner

The examiner can issue when the document's criteria are met

FAA label

ACCEPTABLE

Source: FAA, Biologics, Biosimilars, and Non-Biologics. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA's biologics sheet lists the kinase inhibitors baricitinib, tofacitinib and upadacitinib as acceptable monotherapy medication when the underlying condition qualifies, with a two-week ground trial when starting and no no-fly time after later doses, warning about cardiovascular events and blood clots.

Track your medications
Compare FAA documents: JAK inhibitorsWhat each of the two FAA documents says, in plain wordsOpen

Wait

  • no wait after later doses

The FAA's CACI – Arthritis Worksheet lists them (JAK) among its acceptable medications as any single medication after a 2-week ground trial, with no post-dose observation time, and says the examiner can issue if the pilot meets all of its acceptable certification criteria.

  • 14 days after starting: ground observation
Show the FAA's words: JAK inhibitorsThe official FAA wording: two passages, each with its document and dateOpen
FAA, Biologics, Biosimilars, and Non-Biologics · FAA date 26 August 2026
Initial observation: All require a 2-week no-fly/ground trial to verify no side effects.
ACCEPTABLE BIOLOGICS - MONOTHERAPY MEDICATION Permitted if the underlying condition qualifies; consult the condition pages for details.
Non-Biologic Medications Post-dose Observation No-Fly times. Kinase Inhibitor: baricitinib (Olumiant), tofacitinib (Xeljanz), upadacitinib (Rinvoq). Warn for cardiovascular events and blood clots (VTE) for all, None
FAA, CACI – Arthritis Worksheet · FAA date 29 April 2026
If the applicant meets ALL the acceptable certification criteria listed below, the AME can issue
Janus Associated Kinase Inhibitor (JAK)
Any singe medication listed below after a 2-week ground trial and:
No post-dose observation time:
JAK: baricitinib (Olumiant); tofacitinib (Xeljanz); upadacitinib (Rinvoq)
Sources and dates: JAK inhibitorsTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.