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Stomach

Linaclotide

Guanylate cyclase-C (GC-C) agonist, on the FAA's colitis worksheet
Other names: Linzess

Taken for: Colitis: Crohn's disease, ulcerative colitis, microscopic colitis or irritable bowel syndromeTaking it for something else? The entries here do not cover that use. The FAA may address it in the guidance for your condition. Ask your examiner.

FAA guidance

Acceptable with conditions.

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

Source: FAA, CACI – Colitis Worksheet. FAA date 29 April 2026. Checked by Crosscheck 14 October 2026

For Crohn's disease, ulcerative colitis, microscopic colitis or irritable bowel syndrome, the FAA's CACI – Colitis Worksheet lists linaclotide (Linzess), a guanylate cyclase-C (GC-C) agonist, among the medications for the condition; any other cause of colitis requires an FAA decision.

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More detail: linaclotideThe rest of Crosscheck's reading, in plain wordsOpen

The worksheet says nothing about linaclotide taken for anything else. The worksheet applies with all its other criteria, and the examiner must note in Block 60 one of its statements, which include CACI qualified colitis, and not CACI qualified and deferred.

Show the FAA's words: linaclotideThe official FAA wording: one passage, each with its document and dateOpen
FAA, CACI – Colitis Worksheet · FAA date 29 April 2026
Cause of Colitis
Crohn’s disease, ulcerative colitis, microscopic colitis, or irritable bowel syndrome
Any other causes require an FAA decision.
Medications for condition
One or more of the following:
Guanylate Cyclase-C (GC-C) Agonist
linaclotide (Linzess), plecanatide (Trulance)
AME MUST NOTE in Block 60 one of the following:
CACI qualified colitis. (Documents do not need to be submitted to the FAA.)
NOT CACI qualified. I have deferred. (Submit supporting documents.)
Sources and dates: linaclotideOne FAA document, with the FAA's date and when Crosscheck checked itOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.