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Stomach

Phenazopyridine

Urinary pain reliever
Other names: AZO, AZO Standard, Pyridium

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

A general FAA rule gives a different wait. The specific one applies.

Source: FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly?. FAA date 28 August 2024. Checked by Crosscheck 14 October 2026

The FAA's over-the-counter guide puts phenazopyridine in its "generally safe to fly" column, and says it is generally allowed after an adequate ground trial to monitor for side effects.

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Compare FAA documents: phenazopyridineWhat each of the two FAA documents says, in plain wordsOpen

The FAA's documents differ. The FAA's over-the-counter guide lists this in its generally-safe column and says it is generally allowed after an adequate ground trial, with no number of its own; its general rule for any new medication is 48 hours. The FAA's MedGuide names the medicine itself and gives 24 hours after the first dose, so the MedGuide's wait applies and the guide's general rule is background.

Wait

  • the over-the-counter guide's general rule for any new medication is 48 hours

It adds that symptoms should be resolved other than slight residual irritation. The same row puts oxybutynin in the No Go column, because it can cause sedation and dizziness. The guide's general rule is never to fly after taking a new medication for the first time until at least 48 hours have passed and no side effects are noted.

The FAA's MedGuide names phenazopyridine (Pyridium) as allowed, for urinary tract infections, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: phenazopyridineThe official FAA wording: three passages, each with its document and dateOpen
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
Urinary tract Infections
Pain reliever phenazopyridine (AZO standard)
Oxybutynin (Oxytrol for women
Oxybutynin can cause sedation and dizziness.
Phenazopyridine is generally allowed after adequate ground trial to monitor for side effects. Symptoms should be resolved other than slight residual irritation.
Generic: phenazopyridine
Brand Name: Pyridium
Drug Class: Analgesic, Urinary
Underlying Condition: Urinary tract infections (UTI)
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
NEVER FLY AFTER TAKING A NEW MEDICATION FOR THE FIRST TIME UNTIL AT LEAST 48 HOURS HAVE PASSED AND NO SIDE EFFECTS ARE NOTED.
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: phenazopyridineTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.