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Primidone

Named on the FAA's essential tremor worksheet as not acceptable
Other names: Mysoline

FAA guidance

FAA review required.

Examiner

The examiner defers to the FAA

Source: FAA, CACI – Essential Tremor Worksheet. FAA date 26 July 2023. Checked by Crosscheck 14 October 2026

The FAA's CACI – Essential Tremor Worksheet says: "Gabapentin, primidone (Mysoline), and other potentially sedating medications are not acceptable for aeromedical purposes.

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Compare FAA documents: primidoneWhat each of the two FAA documents says, in plain wordsOpen

Do NOT CACI." It says a beta blocker is the only CACI-eligible medication for essential tremor.

The FAA's Tremor disposition table says the acceptable medication for CACI is none or a beta-blocker and all others go to its row C, which notes that most medication to treat tremor is not acceptable (for example gabapentin, mysoline [primadone]); for that row it says the examiner should defer and submit the information to the FAA for a possible special issuance.

Show the FAA's words: primidoneThe official FAA wording: two passages, each with its document and dateOpen
FAA, CACI – Essential Tremor Worksheet · FAA date 26 July 2023
Gabapentin, primidone (Mysoline), and other potentially sedating medications are not acceptable for aeromedical purposes. Do NOT CACI.
Note: Beta blocker is the ONLY CACI-eligible medication for this condition.
FAA, Essential Tremor · FAA date 25 January 2023
Acceptable medication for CACI is NONE or a beta-blocker. (All others go to Row C).
C. All others
Note: Most medication to treat tremor is not acceptable (e.g., gabapentin, mysoline [primadone]).
DEFER
Submit the information to the FAA for a possible Special Issuance
Sources and dates: primidoneTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.