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Other

TNF blockers

Tumor necrosis factor (TNF) blocking agent, biologic
Other names: adalimumab, Humira, Hadlima, adalimumab-bwwd, etanercept, Enbrel

FAA guidance

Acceptable with conditions.

Wait

2 weeks

ground trial when starting

Different waits apply in other cases.

Examiner

The examiner can issue when the document's criteria are met

FAA label

ACCEPTABLE

Source: FAA, Biologics, Biosimilars, and Non-Biologics. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists adalimumab, certolizumab, etanercept and golimumab as acceptable biologics when the underlying condition qualifies, with a two-week ground trial when starting and four hours of no-fly after each dose; FDA-approved biosimilars count the same.

Track your medications
More detail: TNF blockersThe rest of Crosscheck's reading, in plain wordsOpen

Wait

  • 4 hours no-fly after each dose
  • a forty-eight hour ground trial when changing from one biologic or biosimilar to another for the same indication

Changing from one biologic or biosimilar to another for the same indication requires a 48-hour ground trial.

  • 14 days after starting: ground observation
  • 4 hours after each dose: no flying
Show the FAA's words: TNF blockersThe official FAA wording: two passages, each with its document and dateOpen
FAA, Biologics, Biosimilars, and Non-Biologics · FAA date 26 August 2026
Initial observation: All require a 2-week no-fly/ground trial to verify no side effects.
ACCEPTABLE BIOLOGICS - MONOTHERAPY MEDICATION Permitted if the underlying condition qualifies; consult the condition pages for details.
Tumor Necrosis Factor (TNF) Blocking Agent: adalimumab (Humira), certolizumab (Cimzia), etanercept (Enbrel), golimumab (Simponi), 4 hours
FDA-approved biosimilars are also acceptable for any referenced brand name medication (e.g., Hadlima [adalimumab-bwwd] for Humira [adalimumab]).
FAA, Biologics, Biosimilars, and Non-Biologics · FAA date 26 August 2026
Changing from one biologic/biosimilar to another for the same indication requires a forty-eight (48) hour ground trial to mitigate any aeromedical risk.
Sources and dates: TNF blockersOne FAA document, with the FAA's date and when Crosscheck checked itOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.