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Mental health

Venlafaxine

SNRI antidepressant
Other names: Effexor

FAA guidance

Special issuance required.

FAA label

CONDITIONALLY ACCEPTABLE

Source: FAA, Antidepressant Medications (table). FAA date 27 August 2025. Checked by Crosscheck 14 October 2026

The FAA's antidepressant table lists venlafaxine as conditionally acceptable with a special issuance, used as a single agent, if otherwise qualified.

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Compare FAA documents: venlafaxineWhat each of the two FAA documents says, in plain wordsOpen

The Guide's Antidepressants page says the Authorization decision is made case by case and the examiner may not issue.

Show the FAA's words: venlafaxineThe official FAA wording: two passages, each with its document and dateOpen
FAA, Antidepressant Medications (table) · FAA date 27 August 2025
CONDITIONALLY Acceptable Antidepressant Medications with SI (Used as a single agent, if otherwise qualified.) — Serotonin and norepinephrine reuptake inhibitors (SNRI): desvenlafaxine (Pristiq), duloxetine (Cymbalta), venlafaxine (Effexor)
FAA, Antidepressants · FAA date 24 April 2024
The Authorization decision is made on a case-by-case basis. The AME may not issue.
Sources and dates: venlafaxineTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.