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Sleep

Zolpidem: Edluar and Intermezzo

Prescription sleep aid
Other names: Edluar, Intermezzo

FAA guidance

Do not fly while taking it.

Wait

36 hours

after the last dose

Source: FAA, Sleep Aids. FAA date 7 May 2025. Checked by Crosscheck 14 October 2026

The FAA sets a 36-hour minimum wait after Edluar (zolpidem that dissolves under the tongue) and Intermezzo (zolpidem for middle of the night awakening); it says the different formulations of zolpidem have different wait times.

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More detail: zolpidem: Edluar and IntermezzoThe rest of Crosscheck's reading, in plain wordsOpen

It says occasional or limited use of sleep aids, such as for circadian rhythm disruption in commercial air operations, is allowable for pilots, and daily or nightly use of sleep aids is not allowed regardless of the underlying cause or reason.

  • 36 hours after the last dose: no flying

FAA rule for sleep medication: The FAA puts all currently available sleep aids on its Do Not Fly list, prescription and over-the-counter alike, and if the pilot uses one routinely, the FAA's table says the examiner should defer. Its sleep aids page says occasional or limited use of sleep aids, such as for circadian rhythm disruption in commercial air operations, is allowable for pilots, and daily or nightly use of sleep aids is not allowed regardless of the underlying cause or reason. It also says medical conditions that chronically interfere with sleep are disqualifying regardless of whether a sleep aid is used or not. FAA, DO NOT ISSUE – DO NOT FLY Medications and general No Fly wait times

Show the FAA's words: zolpidem: Edluar and IntermezzoThe official FAA wording: one passage, each with its document and dateOpen
FAA, Sleep Aids · FAA date 7 May 2025
Required minimum waiting time after last dose before resuming pilot duties
Because of the potential for impairment, we require a minimum wait time between the last dose of a sleep aid and performing pilot duties.
The minimum required wait time after the last dose of a sleep aid is 5-times the maximum elimination half life.
Edluar, zolpidem (dissolves under the tongue), 36 hours. Intermezzo, zolpidem (for middle of the night awakening), 36 hours
The different formulations of zolpidem have different half-lives, thus different wait times.
Occasional or limited use of sleep aids, such as for circadian rhythm disruption in commercial air operations, is allowable for pilots. Daily/nightly use of sleep aids is not allowed regardless of the underlying cause or reason.
Sources and dates: zolpidem: Edluar and IntermezzoOne FAA document, with the FAA's date and when Crosscheck checked itOpen
  • Sleep Aids

    FAA date 7 May 2025 · Checked by Crosscheck 14 October 2026 · Web page

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.