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Pain

Acetaminophen

Analgesic
Other names: Tylenol, Panadol

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

A general FAA rule gives a different wait. The specific one applies.

FAA label

GENERALLY SAFE TO FLY

Source: FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly?. FAA date 28 August 2024. Checked by Crosscheck 14 October 2026

The FAA's over-the-counter guide lists acetaminophen among the pain relievers in its "Generally Safe to Fly" column, as long as the underlying condition is acceptable.

Track your medications
Compare FAA documents: acetaminophenWhat each of the two FAA documents says, in plain wordsOpen

The FAA's documents differ. The FAA's over-the-counter guide lists this in its generally-safe column and gives it no wait of its own; its general rule for any new medication is 48 hours. The FAA's MedGuide names the medicine itself and gives 24 hours after the first dose, so the MedGuide's wait applies and the guide's general rule is background.

Wait

  • the over-the-counter guide's general rule for any new medication is 48 hours

It cautions that some OTC meds are combined with a sedating antihistamine, which can cause drowsiness. The guide also says never to fly after taking a new medication for the first time until at least 48 hours have passed and no side effects are noted.

The FAA's MedGuide names acetaminophen (Tylenol, Panadol) as allowed, for pain management and fever, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: acetaminophenThe official FAA wording: three passages, each with its document and dateOpen
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
acetaminophen (Tylenol), aspirin (Bayer), ibuprofen (Advil/Motrin), naproxen (Naprosyn). Most OTC pain meds are safe to fly as long as the underlying condition is acceptable. CAUTION: Some OTC meds are combined with a sedating antihistamine, which can cause drowsiness (see antihistamine row).
Generic: acetaminophen; paracetamol
Brand Name: Tylenol; Panadol
Drug Class: Analgesic
Underlying Condition: Pain management; Fever
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
NEVER FLY AFTER TAKING A NEW MEDICATION FOR THE FIRST TIME UNTIL AT LEAST 48 HOURS HAVE PASSED AND NO SIDE EFFECTS ARE NOTED.
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: acetaminophenTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.