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Allopurinol

Other names: Aloprim, Zyloprim

The FAA's guidance for allopurinol depends on what it is taken for. Each use is below, with its own FAA source and date.

Taken for retained kidney stones

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

Source: FAA, CACI – Retained Kidney Stone(s) Worksheet. FAA date 27 April 2022. Checked by Crosscheck 14 October 2026

For retained kidney stones, the FAA's CACI worksheet says supportive treatments such as hydration or medications, naming thiazides, allopurinol and potassium citrate, to decrease recurrence, with no side effects, are allowed.

Track your medications
Compare FAA documents: allopurinolWhat each of the two FAA documents says, in plain wordsOpen

The examiner must note in Block 60 one of the worksheet's statements, which include CACI qualified retained kidney stones, in which case documents do not need to be submitted to the FAA, and not CACI qualified, the examiner having deferred. The worksheet says nothing about allopurinol taken for anything else; allopurinol for gout has its own entry.

The FAA's MedGuide names allopurinol (Aloprim, Zyloprim) as allowed, for gout, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used as prescribed. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: allopurinolThe official FAA wording: two passages, each with its document and dateOpen
FAA, CACI – Retained Kidney Stone(s) Worksheet · FAA date 27 April 2022
Current or recommended treatment
Supportive treatments such as hydration or medications (such as thiazides, allopurinol, or potassium citrate) to decrease recurrence (with no side effects) are allowed.
AME MUST NOTE in Block 60 one of the following:
CACI qualified Retained Kidney Stone(s). (Documents do not need to be submitted to the FAA.)
NOT CACI qualified Retained Kidney Stone(s). I have deferred.
Generic: allopurinol
Brand Name: Aloprim; Zyloprim
Drug Class: Xanthine oxidase inhibitor
Underlying Condition: Gout
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: As prescribed
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: allopurinolTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

Taken for gout or pseudogout

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

Examiner

The examiner can issue when the document's criteria are met

Source: FAA, Gout and Pseudogout. FAA date 27 April 2015. Checked by Crosscheck 14 October 2026

For gout or pseudogout that is well controlled, the FAA's gout table says the examiner may issue when the interview and examination reveal no persistent symptoms or functional impairment, and medication combinations of NSAIDs, uric acid reducers (allopurinol, etc.) or uric acid excreters (probenecid) with no aeromedically significant side effects, noting the findings in block 60; with functional impairment, joint deformity, recurrent kidney stones, other medications, gout that is not controlled or persistent symptoms, the examiner defers and submits records to the FAA for decision.

Compare FAA documents: allopurinolWhat each of the two FAA documents says, in plain wordsOpen

The FAA's MedGuide names allopurinol (Aloprim, Zyloprim) as allowed, for gout, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used as prescribed. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: allopurinolThe official FAA wording: three passages, each with its document and dateOpen
FAA, Gout and Pseudogout · FAA date 27 April 2015
Gout
Pseudogout
Well controlled
Interview and examination reveal: ☐ No persistent symptoms or functional impairment.
☐ Med combinations of NSAIDS, uric acid reducers (allopurinol, etc.), or uric acid excreters (probenecid) with no aeromedically significant side effects.
ISSUE
Note findings in block 60.
Generic: allopurinol
Brand Name: Aloprim; Zyloprim
Drug Class: Xanthine oxidase inhibitor
Underlying Condition: Gout
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: As prescribed
FAA, Gout and Pseudogout · FAA date 27 April 2015
Functional impairment
Joint deformity
Kidney stones, recurrent
Meds other than above
Not controlled
Persistent symptoms
Submit a current status report that addresses:
DEFER
Submit records to the FAA for decision
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: allopurinolTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

Taking it for something else? The entries here do not cover that use. The FAA may address it in the guidance for your condition. Ask your examiner.

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.