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Migraine

CGRP injections and Qulipta for migraine prevention

CGRP receptor antagonist, migraine prevention
Other names: atogepant, Qulipta, erenumab, Aimovig, eptinezumab, Vyepti

FAA guidance

Acceptable with conditions.

Wait

7 days

ground trial when starting

There is more to this wait.

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

FAA label

CACI ACCEPTABLE

Source: FAA, Migraine Medication. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists atogepant, erenumab, eptinezumab, fremanezumab and galcanezumab as CACI-acceptable migraine prevention medication with a seven-day ground trial when starting and no no-fly time listed.

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More detail: CGRP injections and Qulipta for migraine preventionThe rest of Crosscheck's reading, in plain wordsOpen

Wait

  • no wait after later doses

The FAA says the list is not all inclusive for individual medications in a noted class, and that a ground trial must verify no adverse effects and effectiveness from the medication before initial consideration.

  • 7 days after starting: ground observation

FAA rule for migraine medication: The FAA says migraine relief or rescue medication is acceptable when used occasionally and unacceptable for daily use, and that its post-dose observation time (no-fly warning) is based on the drug's half-life. It says that if several relief medications are needed on a recurring basis to stop symptoms, this is considered a complicated migraine, and the examiner should defer. For relief or rescue medication the worksheet lists, the FAA's CACI – Migraine and Chronic Headache Worksheet says the examiner can issue if the pilot meets all of its acceptable certification criteria, which include no more than one episode per month, no more than 2 outpatient clinic or urgent care visits for symptom exacerbation in the last 12 months (even if symptoms fully resolved), and no history of in-patient hospitalizations for headaches; it says narcotics, Fiorinal, Fioricet and Midrin are not acceptable for relief or rescue. FAA, Migraine Medication

Show the FAA's words: CGRP injections and Qulipta for migraine preventionThe official FAA wording: one passage, each with its document and dateOpen
FAA, Migraine Medication · FAA date 26 August 2026
Must have ground trial to verify no adverse effects and effectiveness from medication prior to initial consideration.
CACI ACCEPTABLE – Migraine Prevention (Prophylaxis). This list is not all inclusive for individual medications in a noted class.
Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist: atogepant (Qulipta), erenumab (Aimovig), eptinezumab (Vyepti), fremanezumab (Ajovy), galcanezumab (Emgality), 7 days, None
Sources and dates: CGRP injections and Qulipta for migraine preventionOne FAA document, with the FAA's date and when Crosscheck checked itOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.