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Migraine

Ergot derivatives for migraine

Ergot derivative, migraine rescue
Other names: dihydroergotamine, Migranal, DHE, ergotamine + caffeine, Wigraine, Cafergot

FAA guidance

Acceptable with conditions.

Wait

48 hours

after each dose of dihydroergotamine

Different waits apply in other cases.

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

FAA label

CACI ACCEPTABLE

Source: FAA, Migraine Medication. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA's migraine medication sheet lists dihydroergotamine (48-hour post-dose observation) and ergotamine with caffeine (24 hours) as CACI-acceptable migraine rescue medication, acceptable when used occasionally and unacceptable for daily use.

Track your medications
Compare FAA documents: Ergot derivatives for migraineWhat each of the two FAA documents says, in plain wordsOpen

Wait

  • 24 hours after each dose of ergotamine + caffeine

The FAA's CACI – Migraine and Chronic Headache Worksheet lists triptans, metoclopramide, ondansetron, promethazine, ubrogepant and rimegepant among its relief/rescue medications and does not name an ergot derivative; it says a detailed list of migraine medications and their no-fly times can be found in the FAA's pharmaceutical guidance on migraine medications, which is the sheet that lists the ergots. Both are quoted.

  • dihydroergotamine: 48 hours after each dose: ground observation
  • ergotamine + caffeine: 24 hours after each dose: ground observation

FAA rule for migraine medication: The FAA says migraine relief or rescue medication is acceptable when used occasionally and unacceptable for daily use, and that its post-dose observation time (no-fly warning) is based on the drug's half-life. It says that if several relief medications are needed on a recurring basis to stop symptoms, this is considered a complicated migraine, and the examiner should defer. For relief or rescue medication the worksheet lists, the FAA's CACI – Migraine and Chronic Headache Worksheet says the examiner can issue if the pilot meets all of its acceptable certification criteria, which include no more than one episode per month, no more than 2 outpatient clinic or urgent care visits for symptom exacerbation in the last 12 months (even if symptoms fully resolved), and no history of in-patient hospitalizations for headaches; it says narcotics, Fiorinal, Fioricet and Midrin are not acceptable for relief or rescue. FAA, Migraine Medication

Show the FAA's words: Ergot derivatives for migraineThe official FAA wording: two passages, each with its document and dateOpen
FAA, Migraine Medication · FAA date 26 August 2026
ACCEPTABLE when used occasionally. Unacceptable for daily use.
CACI ACCEPTABLE - Migraine Relief/Rescue Medication
Ergot Derivative: dihydroergotamine (Migranal), ergotamine + caffeine (Wigraine), 48 hours, 24 hours
FAA, CACI – Migraine and Chronic Headache Worksheet · FAA date 26 August 2026
Medications or treatment - Relief/Rescue
NOT acceptable: Narcotics, Fiorinal, Fioricet, or Midrin.
None; or Over the Counter (OTC) headache medications; or other modalities such as heat, traction, acupressure, and massage devices, to prevent, stop, and treat headaches.
One or more of the following:
Triptans (monotherapy or with NSAID combination) 24 hour no-fly Except eletriptan (Relpax) and frovatriptan (Frova): 48 hours
metoclopramide (Reglan): 36 hour no-fly
ondansetron (Zofran): 24 hour no-fly
promethazine (Phenergan): 96 hour no-fly
Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist with 24 hour no fly time: ubrogepant (Ubrelvy); Rimegepant (Nurtec)
Detailed list of migraine medications and no fly/no SRD time after use can be found Pharmaceuticals - Migraine Medications
Sources and dates: Ergot derivatives for migraineTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.