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Allergy and cold

Guaifenesin

Expectorant
Other names: Mucinex, Robitussin, Duratuss

FAA guidance

Acceptable with conditions.

Wait

24 hours

after the first dose (the FAA's MedGuide)

FAA label

GENERALLY SAFE TO FLY

Source: FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly?. FAA date 28 August 2024. Checked by Crosscheck 14 October 2026

The FAA's over-the-counter guide lists guaifenesin (found in Mucinex and Robitussin) in its "Generally Safe to Fly" column, with caution because combination products may contain sedating antihistamines; if the label states PM (for nighttime use) or DM (containing dextromethorphan), it says not to fly while using these medications and for at least 5 dosage intervals after the last dose.

Track your medications
Compare FAA documents: guaifenesinWhat each of the two FAA documents says, in plain wordsOpen

The FAA's MedGuide names guaifenesin (Mucinex, Duratuss) as allowed, for congestion, with a wait of 24 hours after the first dose and none after later doses or after the final dose, used per label directions. The MedGuide defines allowed as acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.

  • 24 hours after the first dose: ground observation
Show the FAA's words: guaifenesinThe official FAA wording: two passages, each with its document and dateOpen
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
GENERALLY SAFE TO FLY
GO
guaifenesin (found in Mucinex and Robitussin)
Most cough medications are safe for flight. Use caution as combination products may contain sedating antihistamines. If the label states PM (for nighttime use) or DM (containing dextromethorphan), you should not fly while using these medications and for at least 5 dosage intervals after the last dose (see Dosage Interval Timetable).
Generic: guaiFENesin
Brand Name: Mucinex; Duratuss [INTL]
Drug Class: Expectorant
Underlying Condition: Congestion
Use: ALLOW
INITIAL Wait Time (after first dose): 24 hours
SUBSEQUENT Dose Wait Time (after each dose): None
DISCONTINUATION Wait Time (after final dose): None
Frequency Use Limit: Per label directions
FAA, MedGuide (FAA Office of Aerospace Medicine medication reference) · FAA date 1 October 2026
ALLOWED: The medication is acceptable for use while performing flight or safety-related duties, provided the condition is stable/aeromedically acceptable and no adverse side effects are present.
Sources and dates: guaifenesinTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.