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Allergy and cold medications

What published FAA guidance says about 31 medications Crosscheck files under allergy and cold medications: each one's answer and, where there is one, its wait. Open a medication for the FAA's own words, the source and its date.

  • Allergy shots and under-the-tongue immunotherapy

    Acceptable with conditions · Wait: 48 hours after the first dose, then 4 hours after each later doseAlso called allergy injections, SLIT, Grastek, Odactra

  • Antihistamine eye drops

    Acceptable with conditions · Wait: 48 hours ground trial after first use of any new medicationAlso called Pataday, Patanol, Pazeo, ketotifen

  • Azelastine + fluticasone (nasal)

    Acceptable with conditions · Wait: 48 hours after the first doseAlso called Dymista

  • Azelastine nasal spray

    Acceptable with conditions · Wait: 48 hours ground trial after first use of any new medicationAlso called Astepro, Astelin

  • Brompheniramine

    Acceptable with conditions · Wait: The allergy sheet's table does not say which of its times is brompheniramine'sAlso called Dimetapp

  • Cetirizine

    Acceptable with conditionsAlso called Zyrtec, Zerviate

  • Chlorpheniramine

    Do not fly while taking it · Wait: 5 days after the last doseAlso called ChlorTrimeton, Coricidin HBP Cough & Cold

  • Clemastine

    Acceptable with conditions · Wait: 5 days the FAA's over-the-counter guideAlso called Tavist

  • Cromolyn (nasal)

    Acceptable in the FAA document citedAlso called NasalCrom

  • Desloratadine

    Acceptable with conditions · Wait: 48 hours ground trial after first use of any new medicationAlso called Clarinex

  • Dextromethorphan

    Do not fly while taking it · Wait: At least 5 dosage intervals after the last dose (over-the-counter guide)Also called Delsym, Robitussin DM, DayQuil

  • Diphenhydramine

    Differs by how it is takenAlso called Benadryl, ZzzQuil, Tylenol PM, Advil PM

  • Doxylamine

    Acceptable with conditions · Wait: 60 hours after the last doseAlso called Unisom, NyQuil

  • Ebastine

    Acceptable with conditions · Wait: 48 hours after the first doseAlso called Ebast

  • Fexofenadine

    Acceptable with conditions · Wait: 48 hours ground trial after first use of any new medicationAlso called Allegra

  • Guaifenesin

    Acceptable with conditions · Wait: 24 hours after the first dose (the FAA's MedGuide)Also called Mucinex, Robitussin, Duratuss

  • Guaifenesin + phenylephrine

    Acceptable with conditions · Wait: 24 hours after the first doseAlso called Deconex IR

  • Guaifenesin + pseudoephedrine

    Acceptable with conditions · Wait: 24 hours after the first doseAlso called Mucus-D, Duratuss GP, Entex

  • Ipratropium (nasal)

    Acceptable with conditions · Wait: 48 hours after the first doseAlso called Ipravent

  • Levocetirizine

    Acceptable with conditions · Wait: Initial observation time of 48 hours, as noted in the allergy sheet's table, or 5 times the half-life or maximal dosing interval after the last doseAlso called Xyzal

  • Loratadine

    Acceptable with conditions · Wait: 48 hours ground trial after first use of any new medicationAlso called Claritin, Alavert

  • Montelukast

    Acceptable with conditionsAlso called Singulair

  • Motion sickness medication: dimenhydrinate and meclizine

    Do not fly while taking itAlso called dimenhydrinate, Dramamine, meclizine, Antivert

  • NyQuil and other night-time cold products

    Do not fly while taking it · Wait: At least 5 dosage intervals after the last dose (over-the-counter guide)Also called NyQuil, Coricidin HBP Cough & Cold, Theraflu Nighttime

  • Olopatadine + mometasone (nasal)

    Acceptable with conditions · Wait: 48 hours after the first doseAlso called Ryaltris

  • Olopatadine nasal spray

    Acceptable with conditions · Wait: 48 hours after the first dose (the FAA's MedGuide)Also called Patanase

  • Phenylephrine

    Generally acceptableAlso called Sudafed PE

  • Pseudoephedrine

    Acceptable with conditions · Wait: 24 hours after the first dose (the FAA's MedGuide, which gives Allegra-D and Claritin-D 48 hours)Also called Sudafed, Efidac

  • Remibrutinib

    Acceptable with conditions · Wait: 2 weeks after the first doseAlso called Rhapsido

  • Steroid nasal sprays

    Acceptable with conditions · Wait: no wait after the first dose or after later doses (the FAA's MedGuide)Also called Flonase, Veramyst, Xhance, Nasonex

  • Tyloxapol (inhalation)

    Acceptable in the FAA document citedAlso called Enuclene

Other groups of medications

Every medication Crosscheck has an FAA answer for, by group or from A to Z, with the answer and the wait on each line. New from the FAA in October 2026: the FAA's MedGuide, explained.

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.