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Migraine

Lasmiditan

Other names: Reyvow

The FAA's guidance for lasmiditan depends on what it is taken for. Each use is below, with its own FAA source and date.

Taken for stopping a migraine

FAA guidance

Special issuance required.

Wait

48 hours

after each dose

FAA label

SI CONDITIONAL

Source: FAA, Migraine Medication. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists lasmiditan as SI-conditional migraine rescue medication with a 48-hour post-dose observation.

Track your medications
More detail: lasmiditanThe rest of Crosscheck's reading, in plain wordsOpen

The FAA lists it separately as unacceptable for migraine prevention, which has its own entry.

  • 48 hours after each dose: ground observation

FAA rule for migraine medication: The FAA says migraine relief or rescue medication is acceptable when used occasionally and unacceptable for daily use, and that its post-dose observation time (no-fly warning) is based on the drug's half-life. It says that if several relief medications are needed on a recurring basis to stop symptoms, this is considered a complicated migraine, and the examiner should defer. For relief or rescue medication the worksheet lists, the FAA's CACI – Migraine and Chronic Headache Worksheet says the examiner can issue if the pilot meets all of its acceptable certification criteria, which include no more than one episode per month, no more than 2 outpatient clinic or urgent care visits for symptom exacerbation in the last 12 months (even if symptoms fully resolved), and no history of in-patient hospitalizations for headaches; it says narcotics, Fiorinal, Fioricet and Midrin are not acceptable for relief or rescue. FAA, Migraine Medication

Show the FAA's words: lasmiditanThe official FAA wording: one passage, each with its document and dateOpen
FAA, Migraine Medication · FAA date 26 August 2026
SI CONDITIONAL - Migraine Relief/Rescue Medication
Serotonin 5-HT1F Receptor Agonist: lasmiditan (Reyvow), 48 hours
Sources and dates: lasmiditanOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Taken for migraine prevention

lasmiditan for migraine prevention

FAA guidance

Do not issue.

Examiner

Do not issue: the examiner cannot issue a certificate

FAA label

UNACCEPTABLE

Source: FAA, Migraine Medication. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists lasmiditan as unacceptable for migraine prevention, its use prohibited as a single agent or in any combination product.

More detail: lasmiditan for migraine preventionThe rest of Crosscheck's reading, in plain wordsOpen

The FAA lists it separately as SI-conditional migraine rescue medication, which has its own entry.

FAA rule for migraine medication: The FAA says migraine relief or rescue medication is acceptable when used occasionally and unacceptable for daily use, and that its post-dose observation time (no-fly warning) is based on the drug's half-life. It says that if several relief medications are needed on a recurring basis to stop symptoms, this is considered a complicated migraine, and the examiner should defer. For relief or rescue medication the worksheet lists, the FAA's CACI – Migraine and Chronic Headache Worksheet says the examiner can issue if the pilot meets all of its acceptable certification criteria, which include no more than one episode per month, no more than 2 outpatient clinic or urgent care visits for symptom exacerbation in the last 12 months (even if symptoms fully resolved), and no history of in-patient hospitalizations for headaches; it says narcotics, Fiorinal, Fioricet and Midrin are not acceptable for relief or rescue. FAA, Migraine Medication

Show the FAA's words: lasmiditan for migraine preventionThe official FAA wording: one passage, each with its document and dateOpen
FAA, Migraine Medication · FAA date 26 August 2026
UNACCEPTABLE – Migraine Prevention (Prophylaxis)
Use prohibited as a single agent or in any combination product.
lasmiditan (Reyvow) [unacceptable for prophylaxis/prevention]
Sources and dates: lasmiditan for migraine preventionOne FAA document, with the FAA's date and when Crosscheck checked itOpen

Taking it for something else? The entries here do not cover that use. The FAA may address it in the guidance for your condition. Ask your examiner.

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.