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Migraine

Nausea medication used with a migraine

Anti-nausea medication, migraine rescue
Other names: ondansetron, Zofran, metoclopramide, Reglan, promethazine, Phenergan

FAA guidance

Acceptable with conditions.

Wait

36 hours

after each dose of metoclopramide

Different waits apply in other cases.

Examiner

CACI: the examiner can issue when the condition's worksheet criteria are met. Applicants for first- or second-class must provide the worksheet's information annually; applicants for third-class with each required exam

FAA label

CACI ACCEPTABLE

Source: FAA, Migraine Medication. FAA date 26 August 2026. Checked by Crosscheck 14 October 2026

The FAA lists metoclopramide (36-hour post-dose observation), ondansetron (24 hours) and promethazine (96 hours) as CACI-acceptable for nausea and vomiting associated with migraine, acceptable when used occasionally and unacceptable for daily use.

Track your medications
Compare FAA documents: Nausea medication used with a migraineWhat each of the two FAA documents says, in plain wordsOpen

Wait

  • 24 hours after each dose of ondansetron
  • 96 hours after each dose of promethazine

The FAA's CACI – Migraine and Chronic Headache Worksheet lists the same three among its relief/rescue medications, with a 36-hour, 24-hour and 96-hour no-fly time.

  • metoclopramide: 36 hours after each dose: ground observation
  • ondansetron: 24 hours after each dose: ground observation
  • promethazine: 96 hours after each dose: ground observation

FAA rule for migraine medication: The FAA says migraine relief or rescue medication is acceptable when used occasionally and unacceptable for daily use, and that its post-dose observation time (no-fly warning) is based on the drug's half-life. It says that if several relief medications are needed on a recurring basis to stop symptoms, this is considered a complicated migraine, and the examiner should defer. For relief or rescue medication the worksheet lists, the FAA's CACI – Migraine and Chronic Headache Worksheet says the examiner can issue if the pilot meets all of its acceptable certification criteria, which include no more than one episode per month, no more than 2 outpatient clinic or urgent care visits for symptom exacerbation in the last 12 months (even if symptoms fully resolved), and no history of in-patient hospitalizations for headaches; it says narcotics, Fiorinal, Fioricet and Midrin are not acceptable for relief or rescue. FAA, Migraine Medication

Show the FAA's words: Nausea medication used with a migraineThe official FAA wording: two passages, each with its document and dateOpen
FAA, Migraine Medication · FAA date 26 August 2026
ACCEPTABLE when used occasionally. Unacceptable for daily use.
CACI ACCEPTABLE - Migraine Relief/Rescue Medication
Nausea and Vomiting (associated with migraine): metoclopramide (Reglan), ondansetron (Zofran), promethazine (Phenergan), 36 hours, 24 hours, 96 hours
FAA, CACI – Migraine and Chronic Headache Worksheet · FAA date 26 August 2026
Medications or treatment - Relief/Rescue
One or more of the following:
metoclopramide (Reglan): 36 hour no-fly
ondansetron (Zofran): 24 hour no-fly
promethazine (Phenergan): 96 hour no-fly
Sources and dates: Nausea medication used with a migraineTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.