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Pain

PM pain products

Pain reliever combined with diphenhydramine
Other names: Advil PM, Tylenol PM, Aleve PM

FAA guidance

Do not fly while taking it.

Wait

60 hours

after diphenhydramine (the FAA's Do Not Fly table)

If used routinely

The examiner should defer

FAA label

NO GO

Source: FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly?. FAA date 28 August 2024. Checked by Crosscheck 14 October 2026

The FAA's over-the-counter guide marks Advil PM and Tylenol PM as No Go, among the products to avoid, which it says can cause incapacitation, and says most "PM" medications contain diphenhydramine.

Track your medications
Compare FAA documents: PM pain productsWhat each of the two FAA documents says, in plain wordsOpen

The guide says to wait at least five dosage intervals after the last dose before flying if the pilot takes any of its No Go medications or has previously had side effects from the medication.

The FAA's Do Not Fly table lists diphenhydramine among sedating antihistamines it says are found in many over-the-counter allergy and other types of medications, as a single agent or in any combination product, and says the wait time after diphenhydramine is 60 hours; if the pilot uses it routinely, the FAA's table says the examiner should defer. Both documents are quoted.

Show the FAA's words: PM pain productsThe official FAA wording: three passages, each with its document and dateOpen
FAA, What Over-the-Counter (OTC) Medications Can I Take and Still Be Safe to Fly? · FAA date 28 August 2024
4. NO GO Medications:
If you take any of the NO GO medications listed in the OTC Medications Reference Table OR if you have previously had side effects from the medication, wait at least five (5) dosage intervals after the last dose before flying.
AVOID
These can cause incapacitation.
NO GO
Advil PM
Tylenol PM
Most “PM” medications contain diphenhydramine
Read the label.
FAA, DO NOT ISSUE – DO NOT FLY Medications and general No Fly wait times · FAA date 30 September 2026
DO NOT FLY (DNF) MEDICATIONS
The following medications have aeromedically concerning safety profiles. All medications listed below may cause sedation or drowsiness, impairing cognitive function and seriously degrading pilot performance.
ALLERGY MEDICATIONS (1st GENERATION)
Sedating Antihistamines:
Found in many over-the-counter (OTC) allergy and other types of medications, as a single agent or in any combination product.
Applies to nasal, ophthalmic, AND oral formulations.
diphenhydramine (Benadryl)
chlorpheniramine (Coricidin; ChlorTrimeton)
SEDATIVES/SLEEP AIDS
Diphenhydramine (Benadryl) - Many OTC sleep aids contain diphenhydramine as the active ingredient (see sedating antihistamines above).
The wait time after diphenhydramine is 60 hours (based on maximum pharmacologic half-life)
FAA, DO NOT ISSUE – DO NOT FLY Medications and general No Fly wait times · FAA date 30 September 2026
DO NOT FLY (DNF) MEDICATIONS
AMEs should caution pilots on use and provide additional No Fly wait times where applicable. If applicant is using the following medications routinely, AMEs should DEFER.
Sources and dates: PM pain productsTwo FAA documents, with the FAA's date and when Crosscheck checked themOpen

See also

Medication guidance alone does not determine whether a pilot is medically qualified to fly. The underlying condition, dosage, side effects, medication combinations, and certification history may affect FAA eligibility.

For informational purposes only. Not legal or medical advice.